Systematic Literature Review
& Network Meta-Analysis

Enabling Evidence-Based Decision Making

Before engaging with payers and reimbursement bodies, it is critical to have a full picture of the evidence supporting your product’s proposition. Evidence-based decision making is a key facet of the reimbursement and market access journey.

Market access and HEOR teams use the evidence generated through systematic literature reviews, network meta-analyses and other statistical methodologies to inform internal decisions about a product’s strategy.

A robust evidence base can help inform decisions around:

Critically, these evidence methodologies also form a key component of health technology assessment submissions, providing the evidence that enables reimbursement bodies to systematically evaluate whether a new treatment should be recommended for patient access.

Our experienced in-house team use the latest techniques and methods to develop focused research questions and protocols, as well as process and summarise the evidence found.

Choosing The Right Evidence Generation Methodology

Do you need a full systematic literature review, or would a rapid review address your requirements in a more timely and cost-effective way?

Would a network meta-analysis add to your evidence base?

How can statistical analyses support your market access and reimbursement goals?

The right approach will depend on your project goals. A full systematic literature review is the gold standard for evidence generation and is required by most HTA bodies. However, if you are looking to build an evidence base to support internal decision-making and inform strategy, a rapid review may be a useful option to consider.

Our in-house systematic literature review analysts and data scientists draw on years of experience developing and reviewing evidence bases for both industry and HTA bodies, to recommend the best evidence methodologies to meet your needs.

To discuss your evidence requirements with our experts, get in touch using the form below.

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    Choosing the right systematic literature review

    Here we explore the different options for literature reviews, including:

    • The gold-standard systematic literature review – Aims to identify all evidence relating to the research question to build a complete evidence base that avoids opinion and bias
    • Rapid or targeted review – An accelerated review that uses a streamlined methodology
    • Scoping review – A review that looks at the size of the evidence base rather than the data within it
    • Review of reviews – Reviews existing systematic literature reviews in the disease area and field of interest
    • Living review – A review that is updated regularly to incorporate new evidence
    Read more
    Which literature review is right for you?
    Click on the above infographic to enlarge

    Finding the evidence

    Our information specialist has extensive experience in developing strategies to identify the widest spectrum of available evidence. This may include searches of sources such as:

    • Databases, including Embase®, MEDLINE® and EconLit
    • Conference proceedings
    • Relevant systematic reviews
    • Reference lists of relevant studies

    Creating an extensive and robust search plan that builds in multiple independent approaches of identifying relevant evidence is of key importance to finding and assessing studies that can inform the research question.

    Choosing the right statistical analysis

    With an in-house specialist statistician, we can further enhance your evidence base with meta-analyses, network meta-analyses and wider statistical analyses. We take a stepwise approach to ensure appropriate analyses are conducted that reflect your evidence base and project requirements.

    We can conduct both fixed- and random-effect meta-analysis as appropriate and explore heterogeneity, where feasible, using subgroup analyses or network meta-regression analyses to adjust for pre-specified covariates.

    We have experience with the following statistical methodologies:

    • Network meta-analysis
      • Bayesian analyses
      • Frequentist analyses
    • Bucher indirect treatment comparisons
    • Pair-wise meta-analysis

    Work with our Evidence experts

    Honestly, the best agency I have ever worked with. It felt like we were working with a partner and not an agency!

    Global Medical DirectorTop 20 Pharma Company
    Shona Lang

    Shona Lang

    Director

    Research interests:

    • Preclinical systematic reviews
    • Emerging biotech
    • Precision medicine
    • Immunotherapy
    Get to know Shona
    Jodie Worrall – Associate Director

    Jodie Worrall

    Director

    Research interests:

    • Rare and complex diseases
    • Systematic literature reviews for the EU JCA
    • Pain management
    • Methodological issues in SLRs
    Get to know Jodie
    Stephen Mitchell – Senior Consultant

    Stephen Mitchell

    Senior Consultant

    Research interests:

    • HTA-compliant systematic reviews
    • Oncology-related systematic reviews
    • Extraction of data to assist with meta-analysis feasibility assessments
    • Living systematic reviews
    Get to know Stephen

    Stephanie Swift

    Senior Consultant

    Research interests:

    • Methodologies and reporting standards
    • Rapid reviews
    • Real-world evidence
    • Personalised medicine
    Get to know Stephanie

    Janine Ross

    Principal Information Specialist

    Research interests:

    • Complex search strategy development
    • Critique of systematic review methods
    • Information retrieval training
    • Identification of real-world evidence and data sources
    Get to know Janine

    Alka Singh

    Consultant

    Research interests:

    • Data visualisation in systematic reviews
    • HTA-compliant systematic reviews
    • Patient-reported outcomes
    • HTA reimbursement landscape
    Get to know
    Alka

    Regina Leadley

    Consultant

    Research interests:

    • Rare diseases
    • Alzheimer’s disease
    • Systematic reviews of disease prevalence and treatment patterns
    • Prognostic/predictive factors
    Get to know Regina

    Rachel Hibbs

    Consultant

    Research interests:

    • Economic (non-clinical) reviews
    • Systematic reviews for rare diseases
    • HTA-compliant systematic reviews
    • Identification/utilisation of patient and carer quality of life/health utility values
    Get to know Rachel

    Emily Hardy

    Consultant

    Research interests:

    • Technology/AI-assisted systematic reviews
    • Feasibility assessments for indirect treatment comparisons
    • Neurobiology
    • Prognostic/predictive reviews
    Get to know Emily
    Shona Lang

    Shona Lang

    Director

    Research interests:

    • Preclinical systematic reviews
    • Emerging biotech
    • Precision medicine
    • Immunotherapy
    Get to know Shona
    Jodie Worrall – Associate Director

    Jodie Worrall

    Director

    Research interests:

    • Rare and complex diseases
    • Systematic literature reviews for the EU JCA
    • Pain management
    • Methodological issues in SLRs
    Get to know Jodie
    Stephen Mitchell – Senior Consultant

    Stephen Mitchell

    Senior Consultant

    Research interests:

    • HTA-compliant systematic reviews
    • Oncology-related systematic reviews
    • Extraction of data to assist with meta-analysis feasibility assessments
    • Living systematic reviews
    Get to know Stephen

    Sarah Batson

    Senior Consultant

    Research interests:

    • HTA-compliant systematic reviews
    • Oncology-related systematic reviews
    • Evidence synthesis methods
    Get to know Sarah

    Stephanie Swift

    Senior Consultant

    Research interests:

    • Methodologies and reporting standards
    • Rapid reviews
    • Real-world evidence
    • Personalised medicine
    Get to know Stephanie

    Janine Ross

    Principal Information Specialist

    Research interests:

    • Complex search strategy development
    • Critique of systematic review methods
    • Information retrieval training
    • Identification of real-world evidence and data sources
    Get to know Janine

    Regina Leadley

    Consultant

    Research interests:

    • Rare diseases
    • Alzheimer’s disease
    • Systematic reviews of disease prevalence and treatment patterns
    • Prognostic/predictive factors
    Get to know Regina

    Rachel Hibbs

    Consultant

    Research interests:

    • Economic (non-clinical) reviews
    • Systematic reviews for rare diseases
    • HTA-compliant systematic reviews
    • Identification/utilisation of patient and carer quality of life/health utility values
    Get to know Rachel

    Emily Hardy

    Consultant

    Research interests:

    • Technology/AI-assisted systematic reviews
    • Feasibility assessments for indirect treatment comparisons
    • Neurobiology
    • Prognostic/predictive reviews
    Get to know Emily

    Alka Singh

    Consultant

    Research interests:

    • Data visualisation in systematic reviews
    • HTA-compliant systematic reviews
    • Patient-reported outcomes
    • HTA reimbursement landscape
    Get to know Alka

    Our evidence scientists are experts in

    • Evidence generation strategy
    • Systematic literature reviews – the gold standard for HTA and published evidence
    • Market landscape systematic literature reviews
    • Rapid reviews
    • Network meta-analysis
    • Critiques of previous systematic literature reviews and meta-analyses
    • Meta-analysis feasibility
    • Bespoke statistical analyses
    • Publication strategy
    Download our Health Economics & Outcome Research

    Uncover our expertise in systematic literature review, network meta-analysis and health economics.

    Download Brochure

    Mtech Access is your go-to consultancy for Evidence Synthesis,
    Systematic Literature Reviews and Meta-analyses

    315
    projects
    36
    clients
    135
    publications
    • At Mtech Access, we have conducted 315+ evidence-synthesis-related projects with 36+ clients*. Of these projects, 60 involved a meta-analysis feasibility and/or subsequent meta-analysis
    • Our team have authored over 135 peer-reviewed journal articles and conference abstracts†
    • We apply rigorous academic protocols to ensure all study questions are appropriately scoped and all relevant search sources examined
    • Systematic literature reviews and meta-analyses are conducted to conform to published guidelines

    *Includes any distinct project involving evidence synthesis for an external Pharmaceutical, Medtech, Biotech or Diagnostics client.

    †Includes publications authored by our team members before they joined Mtech Access.

    • At Mtech Access, we have conducted 235+ evidence-synthesis-related projects with 30+ clients*. Of these projects, 60 involved a meta-analysis feasibility and/or subsequent meta-analysis
    • Our team have authored over 120 peer-reviewed journal articles and conference abstracts
    • We apply rigorous academic protocols to ensure all study questions are appropriately scoped and all relevant search sources examined
    • Systematic literature reviews and meta-analyses are conducted to conform to published guidelines
    • We have in-depth knowledge of global HTA body requirements, with the skills in-house to support your full submission or to supplement your teams’ capability where needed
    • In the UK, we have close relationships with over 80 contracted Associates working in the NHS, who work directly with us on projects as needed, to ensure the validity of our evidence generation

    *Includes any distinct project involving evidence synthesis for an external Pharmaceutical, Medtech, Biotech or Diagnostics client.

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